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[Correlation between prostate specific antigen and histopathologic findings in ileum-obturator node dissection]
C Scorticati1, L Montes de Oca, F Bencardino
1Servicio de Urología, Hospital de Clínicas José de San Martín, Buenos Aires, Argentina.
Objective:
To determine the correlation between PSA values and the histopathological findings of ileo-obturator node dissection in prostatic cancer.
Methods:
We reviewed the data of 51 patients with clinically localized prostatic carcinoma, submitted to ileo-obturator node dissection before definitive treatment of the tumor. The patients were classified into 4 groups according to their previous PSA values: A < 10 ng/ml, B > 10 and < 20 ng/ml, C > 20 and < 50 ng/ml and D < 50 ng/ml.
Results:
Overall 17.6% of the patients had positive lymph nodes; 9.9% of the patients in group A, 15.4% of the patients in group B, 11.1% of those in group C and 41.7% of those in group D had positive nodes. Using 50 ng/ml as the cut-off point, 10% of those with PSA < 50 ng/ml had positive nodes vs 42.3% of those with PSA > 50 ng/ml, which was statistically significant with the Fischer test.
Conclusion:
Preoperative PSA has a statistically significant correlation with positive nodes, considering 50 ng/ml as the cut-off point. PSA determination in patients that have received no treatment is essential in the diagnosis and evaluation of therapy in prostate cancer.