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Related Experiment Videos

Circulating soluble selectins in Kawasaki disease

S Takeshita1, H Dobashi, K Nakatani

  • 1Department of Paediatrics, National Defence Medical College, Tokorozawa, Japan.

Clinical and Experimental Immunology
|June 1, 1997
PubMed
Summary

Circulating soluble selectins (sE-, sP-, sL-selectin) show distinct patterns during Kawasaki disease (KD) progression, reflecting its inflammatory process and aiding in diagnosis.

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Area of Science:

  • Immunology
  • Pediatric Rheumatology
  • Vascular Biology

Background:

  • Kawasaki disease (KD) is an acute febrile illness affecting young children.
  • Leukocyte-endothelial cell interactions are crucial in KD pathogenesis.
  • Adhesion molecules play a role in these inflammatory processes.

Purpose of the Study:

  • To evaluate the role of soluble adhesion molecules in Kawasaki disease.
  • To investigate the kinetics of soluble E-, P-, and L-selectin during KD clinical course.
  • To correlate adhesion molecule levels with inflammatory markers.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum levels.
  • Study included patients with KD, other febrile diseases, Henoch-Schonlein purpura (HSP), and healthy children.

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  • Levels were assessed during acute, subacute, and convalescent phases of KD.

    • Main Results:

    • Significantly elevated serum sE-selectin in acute KD compared to controls (P < 0.01).
    • Significantly elevated serum sP-selectin in subacute KD compared to controls (P < 0.01).
    • Serum sL-selectin levels showed an increasing trend in the convalescent phase.
    • Positive correlations found between sE-selectin and C-reactive protein (r=0.80, P<0.0001).
    • Positive correlations found between sP-selectin and platelet count (r=0.57, P<0.0001).

    Conclusions:

    • Soluble E-, P-, and L-selectin exhibit distinct temporal patterns during Kawasaki disease.
    • These molecules may serve as indicators of the inflammatory process in KD.
    • Adhesion molecule kinetics could aid in understanding KD pathogenesis and monitoring disease activity.