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[Deep venous thromboses and occult cancers]

S Chraibi1, A Bennis, O Kemmou

  • 1Service de Cardiologie, CHU lbn Rochd, Casablanca, Maroc.

Annales De Cardiologie Et D'Angeiologie
|March 1, 1997
PubMed
Summary

A simple assessment can detect underlying cancer in patients with idiopathic deep venous thrombosis (DVT). This systematic screening is recommended for individuals aged 50-85 to improve early cancer diagnosis.

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Area of Science:

  • Oncology
  • Hematology
  • Diagnostic Medicine

Context:

  • The link between venous thrombosis and cancer is well-established, with thrombophlebitis sometimes being the initial presentation of an undiagnosed malignancy.
  • Idiopathic deep venous thrombosis (DVT) in patients aged 50-85 warrants investigation for an underlying cancer.

Purpose:

  • To analyze the association between deep venous thrombosis (DVT) and underlying cancer.
  • To identify elements that guide the diagnosis of cancer in patients presenting with idiopathic DVT.
  • To evaluate the efficacy of a simple diagnostic assessment for detecting cancer in these patients.

Summary:

  • A study of 10 cases of DVT revealing cancer and 75 cases of idiopathic DVT found that a basic assessment (clinical exam, blood counts, ESR, protein electrophoresis, chest X-ray, abdominopelvic ultrasound) detected cancer in 10% of idiopathic DVT cases.

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  • Cancers were diverse (urogenital, lung, stomach, leukemia, liposarcoma), with adenocarcinoma being most common.
  • In most cases, cancer was metastatic, but one localized cancer was curable with surgery.
  • No significant differences in DVT characteristics were found between cancer-associated and idiopathic DVT groups.

    • Impact:

    • Recommends a systematic, simple, and inexpensive cancer screening assessment for all idiopathic DVT cases in patients aged 50-85.
    • Suggests that further, more complex investigations should be guided by the results of this initial assessment.
    • Highlights the importance of considering cancer in the differential diagnosis of unexplained DVT.