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Is familial combined hyperlipidaemia a genetic disorder of adipose tissue?
1Karolinska Institute, Department of Medicine, Huddinge Hospital, Sweden.
Current Opinion in Lipidology
|April 1, 1997
Abstract:
Familial combined hyperlipidaemia is a common cause of coronary heart disease. Its aetiology is heterogeneous. The genetic and metabolic basis of the disorder has not yet been defined. This review discusses the putative role of adipose tissue in the pathogenesis of familial combined hyperlipidaemia. It is possible that mutations in genes regulating the turnover of lipids in fat cells are involved in the aetiology.