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The role of 15-lipoxygenase in atherogenesis: pro- and antiatherogenic actions
1Institute of Biochemistry, University Clinics Charité, Humboldt University, Berlin, Germany.
Current Opinion in Lipidology
|April 1, 1997
Abstract:
Oxidative modification converts LDL to an atherogenic form and 15-lipoxygenase has been implicated in this process. Several lines of experimental evidence support such a proatherogenic action of the enzyme. However, recent data obtained with transgenic rabbits overexpressing 15-lipoxygenase suggest also an antiatherogenic effect. In this paper the pathophysiological relevance of 15-lipoxygenase in atherogenesis is critically reviewed.