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Related Experiment Video

Updated: Jul 13, 2026

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart
11:50

High-frequency High-resolution Echocardiography: First Evidence on Non-invasive Repeated Measure of Myocardial Strain, Contractility, and Mitral Regurgitation in the Ischemia-reperfused Murine Heart

Published on: July 10, 2010

Arbutamine stress echocardiography

T Ketteler1, W Krahwinkel, J Wolfertz

  • 1Wuppertal Heart Center, Department of Cardiology, University of Witten/Herdecke, Germany.

European Heart Journal
|June 1, 1997
PubMed
Summary

Arbutamine is a new drug for pharmacological stress testing that mimics exercise by increasing heart rate. It shows high accuracy in diagnosing coronary artery disease when used with the GenESA system.

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Last Updated: Jul 13, 2026

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Area of Science:

  • Cardiology
  • Pharmacology
  • Medical Imaging

Background:

  • Pharmacological stress testing is crucial for diagnosing coronary artery disease (CAD).
  • Existing methods like exercise echocardiography have limitations.
  • Arbutamine offers a novel pharmacological approach.

Purpose of the Study:

  • To evaluate the clinical utility and safety of arbutamine for pharmacological stress testing.
  • To assess the diagnostic performance of arbutamine in detecting significant stenotic coronary artery disease.
  • To examine the effectiveness of the GenESA computerized drug delivery and monitoring system.

Main Methods:

  • Arbutamine, a beta-adrenoceptor agonist, was administered for pharmacological stress testing.
  • The GenESA system was used for computerized drug delivery and real-time heart rate monitoring.
  • Diagnostic accuracy, sensitivity, and specificity were calculated and compared to exercise echocardiography.

Main Results:

  • Arbutamine demonstrated high diagnostic accuracy (82%), sensitivity (76%), and specificity (96%) for significant CAD.
  • The drug's effects on heart rate and myocardial contractility mimic physical exercise.
  • The GenESA system provided precise drug infusion control based on patient heart rate feedback.

Conclusions:

  • Arbutamine is a well-tolerated and safe option for pharmacological stress testing.
  • The GenESA system enhances the safety and efficacy of arbutamine administration.
  • Arbutamine, with the GenESA system, shows significant promise for diagnosing coronary artery disease.