Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Apoptosis in cancer

Y Kuchino1, C Kitanaka

  • 1Biophysics Division National Cancer Center Research Institute, Tokyo, Japan.

Human Cell
|September 1, 1996
PubMed
Summary

Apoptosis, a programmed cell death, is crucial for normal and malignant processes. Understanding its molecular pathways offers new avenues for effective cancer therapy strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death.

Cell death & disease·2011
Same author

Nestin expression in central nervous system germ cell tumors.

Neurosurgical review·2007
Same author

Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32.

Cell death and differentiation·2004
Same author

Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression.

Biochemical and biophysical research communications·2001
Same author

ASK1-signaling promotes c-Myc protein stability during apoptosis.

Biochemical and biophysical research communications·2001
Same author

The ciliate Euplotes octocarinatus expresses two polypeptide release factors of the type eRF1.

Gene·2001

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Oncology

Background:

  • Apoptosis is a genetically encoded cell death program.
  • It plays a critical role in regulating normal and malignant biological processes.
  • Recent advancements have identified key factors controlling apoptosis, accelerating research into its molecular signaling pathways.

Purpose of the Study:

  • To discuss the role of apoptosis in carcinogenesis.
  • To explore the potential applications of apoptosis in cancer therapy.

Main Methods:

  • Literature review and synthesis of current research on apoptosis.
  • Analysis of molecular mechanisms underlying apoptosis signaling.
  • Discussion of therapeutic strategies targeting apoptosis.

Main Results:

  • Apoptosis is integral to preventing cancer development.
  • Dysregulation of apoptosis contributes to carcinogenesis.
  • Targeting apoptosis pathways presents promising therapeutic opportunities.

Conclusions:

  • Apoptosis is a key regulator in cancer biology.
  • Modulating apoptosis holds significant potential for novel cancer treatments.

Related Experiment Videos