Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathologic factors affecting postsplenectomy survival in dogs

W L Spangler1, P H Kass

  • 1IDEXX Veterinary Services, Inc., Broderick, CA, USA.

Journal of Veterinary Internal Medicine
|May 1, 1997
PubMed
Summary

Splenic nodular lesions in dogs are not always fatal hemangiosarcoma. Pathologic evaluation of 500 spleens revealed nonneoplastic causes for many nodular lesions, significantly impacting dog survival rates post-splenectomy.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Re-evaluation of the low-dose dexamethasone suppression test in dogs.

The Journal of small animal practice·2022
Same author

Functional phenotyping of the CYP2D6 probe drug codeine in the horse.

BMC veterinary research·2021
Same author

Corrigendum to "Comparison of ultrasonic pachymetry and Fourier-domain optical coherence tomography for measurement of corneal thickness in dogs with and without corneal disease" [Vet. J. 242 (2018) 59-66].

Veterinary journal (London, England : 1997)·2020
Same author

Effects of lidocaine on equine ejaculated sperm and epididymal sperm post-castration.

Theriogenology·2019
Same author

Dental and Temporomandibular Joint Pathology of the Kit Fox (Vulpes macrotis).

Journal of comparative pathology·2019
Same author

Comparison of ultrasonic pachymetry and Fourier-domain optical coherence tomography for measurement of corneal thickness in dogs with and without corneal disease.

Veterinary journal (London, England : 1997)·2018

Area of Science:

  • Veterinary Pathology
  • Canine Surgery
  • Surgical Oncology

Background:

  • Splenomegaly and splenic lesions are common in dogs.
  • Splenic nodular lesions are often presumed to indicate hemangiosarcoma, a fatal condition.
  • Splenectomy is a common surgical procedure in veterinary practice.

Purpose of the Study:

  • To correlate complete pathologic evaluation of spleens with postoperative survival data.
  • To differentiate survival outcomes between neoplastic and nonneoplastic splenic lesions.
  • To assess the prognostic significance of splenic nodular lesions and associated hematomas.

Main Methods:

  • Complete pathologic evaluation of 500 spleens from dogs undergoing splenectomy.
  • Classification of splenic lesions as neoplastic or nonneoplastic.

Related Experiment Videos

  • Correlation of histopathologic findings with long-term survival data.

    • Main Results:

    • 48.2% of spleens were neoplastic, and 51.4% were nonneoplastic.
    • Nonneoplastic nodular lesions (lymphoid hyperplasia, hematomas) were frequent.
    • Survival rates differed significantly: 83% 2-month survival for nonneoplastic hematomas vs. 31% for hemangiosarcoma.

    Conclusions:

    • Not all splenic nodular lesions in dogs represent hemangiosarcoma.
    • Accurate pathologic classification is crucial for predicting prognosis after splenectomy.
    • Distinguishing nonneoplastic splenic conditions from hemangiosarcoma significantly impacts survival outcomes.