[Acute poisoning by new psychotropic drugs]

New tricyclic antidepressants such as amineptine and tianeptine have mild toxic effects while amoxapine is very toxic. Poisoning with new selective serotonin reuptake inhibitor antidepressants or monoamine-oxidase inhibitors type A (toloxatone, moclobemide) is usually not severe, but life-threatening serotonin syndromes may appear in case of drug combination with antidepressants. Loxapine and clozapine poisoning may lead to death while risperidone intoxication has usually a rather benign course. Substituted benzamide neuroleptics (amisulpride, sultopride) may induce seizures, QT prolongation and torsades de pointes. New hypnotics such as zolpidem and zopiclone have a mild toxicity similar to that of benzodiazepines, but coma and respiratory depression are observed if other drugs or ethanol are ingested or in case of chronic hepatic or respiratory insufficiency.