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Biological reaction to debris in relation to joint prostheses
P A Revell1, N al-Saffar, A Kobayashi
1Department of Histopathology, Royal Free Hospital, School of Medicine.
Abstract:
Bone loss induced by the inflammatory response to wear particles is a major cause of long-term failure of total joint replacement. This review describes the cellular reaction occurring in response to these particles and what is currently known about the inflammatory mechanisms contributing to bone resorption.