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An Implantable System For Chronic In Vivo Electromyography
Published on: April 21, 2020
Tissue response to chronically stimulated implanted epimysial and intramuscular electrodes
J M Akers1, P H Peckham, M W Keith
1Case Western Reserve University, Cleveland, OH 44106, USA.
IEEE Transactions on Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society
|June 1, 1997
Summary
This study evaluated tissue response to implanted electrodes in dogs. While epimysial electrodes showed better tissue integration, chronic stimulation trended towards poorer outcomes for intramuscular electrodes.
Area of Science:
- Biomedical Engineering
- Tissue Engineering
- Implantable Devices
Background:
- Long-term implantation of electrodes is crucial for various medical applications.
- Understanding the host tissue response to implanted electrodes is essential for device longevity and efficacy.
Purpose of the Study:
- To assess the tissue response to epimysial and intramuscular electrodes in dogs.
- To investigate the effect of chronic electrical stimulation on the tissue encapsulation of these electrodes.
Main Methods:
- Implantation of epimysial and intramuscular electrodes in adult dogs for 11-50 months.
- Application of chronic stimulation to half of the electrodes for eight weeks.
- Histological evaluation of fibrous tissue and inflammatory cell presence around electrodes.
Main Results:
- Epimysial electrodes generally showed better tissue integration scores than intramuscular electrodes.
- Chronic stimulation did not significantly affect epimysial electrode tissue response but showed a trend towards poorer ratings for intramuscular electrodes.
- Fibrous capsule thickness was not correlated with stimulation but was positively correlated with suture loss for epimysial electrodes.
Conclusions:
- Electrode type influences tissue encapsulation, with epimysial placement being more favorable.
- Chronic stimulation may negatively impact intramuscular electrode tissue response.
- Suture integrity is a critical factor in the stability of epimysial electrode encapsulation.
