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Interleukin-8 level in maternal serum as a marker for screening of histological chorioamnionitis at term
K Shimoya1, N Matsuzaki, T Taniguchi
1Department of Gynecology and Obstetrics, Osaka University Medical School, Japan. shimoya@gyne.med.osaka-u.ac.jp
Objective:
To establish a clinical method for immediate diagnosis of histological chorioamnionitis, by maternal blood sampling at term.
Method:
The sera of 22 mothers with chorioamnionitis and 81 mothers without chorioamnionitis at term delivery were collected. The serum levels of cytokines including interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-8 (IL-8) were titered and other conventional markers such as white blood cell and CRP were measured simultaneously. Chorioamnionitis was histopathologically confirmed after delivery.
Result:
The sera of mothers with histological chorioamnionitis showed a significant increase in IL-8 titer, but not in those of other cytokines or conventional markers, compared with those without chorioamnionitis. A positive correlation was observed between maternal and cord serum IL-8 levels. Maternal IL-8 showed the highest predictive value for diagnosis of histological chorioamnionitis.
Conclusion:
Measurement of maternal IL-8 is useful for rapid prenatal screening of histological chorioamnionitis at term.