Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Myxedema

K Hierholzer1, R Finke

  • 1Department of Clinical Physiology, Universitätsklinikum Benjamin Franklin, Freie Universität, Berlin, Germany.

Kidney International. Supplement
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Hypothyroidism causes generalized myxedema through fluid and sodium retention, primarily due to interstitial mucopolysaccharide deposition. This leads to impaired circulation and lymphatic drainage, contributing to edema and hyponatremia.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Diagnostics and treatment of acromegaly : Necessity for targeted monitoring of comorbidities].

Der Internist·2017
Same author

Experimental Arthritis in the Rat Induced by the Superantigen Staphylococcal Enterotoxin A.

Scandinavian journal of immunology·2017
Same author

The influence of physical strain on esophageal motility in healthy volunteers studied with gas-perfusion manometry.

Neurogastroenterology and motility·2015
Same author

[Function of oesophagus and gastro-oesophageal reflux in patients with cystic fibrosis].

Zeitschrift fur Gastroenterologie·2014
Same author

Outcome prediction using clinical scores and biomarkers in patients with presumed severe infection in the emergency department.

Medizinische Klinik, Intensivmedizin und Notfallmedizin·2012
Same author

Case report: ectopic pancreas with pseudocyst and pseudoaneurysm formation.

Clinical radiology·2009
Same journal

Effect of kidney disease on glucose handling (including genetic defects).

Kidney international. Supplement·2011
Same journal

Need for better diabetes treatment for improved renal outcome.

Kidney international. Supplement·2011
Same journal

Glucose dynamics and mechanistic implications of SGLT2 inhibitors in animals and humans.

Kidney international. Supplement·2011
Same journal

SGLT2 inhibitors: molecular design and potential differences in effect.

Kidney international. Supplement·2011
Same journal

Glucose handling by the kidney.

Kidney international. Supplement·2011
Same journal

Bone: from a reservoir of minerals to a regulator of energy metabolism.

Kidney international. Supplement·2011
See all related articles

Area of Science:

  • Endocrinology
  • Pathophysiology
  • Biochemistry

Background:

  • Hypothyroidism is characterized by thyroid hormone deficiency, leading to diverse clinical manifestations.
  • Generalized myxedema is a key feature, resulting from complex pathobiochemical changes.
  • Understanding these mechanisms is crucial for managing hypothyroidism.

Purpose of the Study:

  • To review the pathobiochemical and pathophysiological factors underlying generalized myxedema in hypothyroidism.
  • To elucidate the roles of fluid and sodium retention, and hyponatremia.
  • To discuss the impact of thyroid hormone deficiency on various organ systems.

Main Methods:

  • Review of existing literature on hypothyroidism and myxedema.
  • Analysis of pathobiochemical mechanisms, including interstitial matrix deposition.

Related Experiment Videos

  • Examination of renal and cardiovascular derangements.
  • Inclusion of recent biochemical findings on cellular impacts.

    • Main Results:

    • Reduced thyroid hormone levels cause interstitial deposition of hydrophilic mucopolysaccharides, leading to fluid and sodium retention.
    • Myxedema is largely a lymphatic edema due to impaired circulation and lymphatic drainage.
    • Hyponatremia results from impaired renal sodium reabsorption, not primarily from elevated ADH.
    • Reduced glomerular filtration rate (GFR) impairs renal water excretion.

    Conclusions:

    • Generalized myxedema in hypothyroidism is a multifactorial condition driven by biochemical disturbances.
    • Thyroid hormone deficiency impacts interstitial matrix, cell surface, and intracellular proteins.
    • Pretibial myxedema in Graves' disease represents a distinct autoimmune process.