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Late-onset hemorrhagic cystitis following bone marrow transplantation: a case report
1Academic Department of Pediatric Oncology, St Bartholomew's Hospital, London, UK.
Pediatric Hematology and Oncology
|May 1, 1997
Insights
A child experienced BK virus hemorrhagic cystitis post-bone marrow transplant. Intravesical prostaglandin E2 caused discomfort and did not improve symptoms, with hydration leading to spontaneous recovery.
Area of Science:
- Pediatric Hematology Oncology
- Virology
- Transplantation Immunology
Background:
- BK virus infection is a significant complication following allogeneic bone marrow transplantation.
- Hemorrhagic cystitis, a common manifestation of BK virus, presents a therapeutic challenge.
- Previous reports suggested intravesical prostaglandin E2 as a potential treatment option.
Abstract:
A 7-year-old child developed BK virus-induced hemorrhagic cystitis on day 16 after an allogeneic bone marrow transplant. Contrary to previous reports, intravesical instillation of prostaglandin E2 was associated with considerable discomfort and failed to alleviate symptoms. Supportive treatment thereafter consisted of adequate hydration until the spontaneous resolution of symptoms on day 52.