Related Experiment Videos
Trabeculectomy with intraoperative 5-fluorouracil vs mitomycin C
1Department of Ophthalmology, Stanford University Medical Center, CA 94305-5308, USA. kuldev.singh@forsythe.stanford.edu
American Journal of Ophthalmology
|January 1, 1997
Summary
Mitomycin C is safer and more effective than 5-fluorouracil when used with trabeculectomy surgery for glaucoma patients in West Africa. Both treatments showed similar rates for achieving very low intraocular pressure.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Glaucoma Research
Background:
- Trabeculectomy is a common surgical procedure for open-angle glaucoma.
- Adjunctive medications are used to improve surgical outcomes.
- Intraoperative antimetabolites like 5-fluorouracil (5-FU) and mitomycin C (MMC) are frequently employed.
Purpose of the Study:
- To compare the efficacy and safety of intraoperative 5-FU versus mitomycin C as adjuncts to trabeculectomy.
- To evaluate outcomes in a specific demographic: black patients in West Africa.
Main Methods:
- Prospective randomized study involving 85 eyes of 85 patients with open-angle glaucoma.
- Patients received either 5-FU (50 mg/ml) or mitomycin C (0.5 mg/ml) soaked sponge during trabeculectomy.
- Intraocular pressure (IOP) and complications were monitored postoperatively.
Main Results:
- Mitomycin C group: 93.2% achieved IOP < 21 mm Hg vs. 73.0% for 5-FU (P = .01).
- Mean postoperative IOP was lower in the mitomycin C group (13.7 mm Hg) compared to the 5-FU group (16.3 mm Hg, P = .05).
- No significant differences in complications or visual acuity were observed between groups.
Conclusions:
- Mitomycin C is a safe and more efficacious adjunct to trabeculectomy than 5-FU in this West African population.
- While mitomycin C led to lower mean IOP, the proportion achieving very low IOP (<15 mm Hg) was not statistically significantly different between the two agents.