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Related Experiment Videos

Optic disk appearance in pseudoexfoliation syndrome

J B Jonas1, K I Papastathopoulos

  • 1Department of Ophthalmology, University Erlangen-Nürnberg, Germany. JOST.JONAS@augen.med.uni.etlangen.de

American Journal of Ophthalmology
|February 1, 1997
PubMed
Summary

Eyes with pseudoexfoliation syndrome have a smaller optic disk, but optic disk appearance is similar between pseudoexfoliative glaucoma and primary open-angle glaucoma. A small optic disk does not increase glaucoma risk in pseudoexfoliation syndrome.

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Optic Nerve Imaging

Background:

  • Pseudoexfoliation syndrome is a common cause of secondary glaucoma.
  • The optic disk appearance in pseudoexfoliation syndrome requires further characterization.
  • Differentiating optic disk changes in pseudoexfoliative glaucoma from other glaucomatous conditions is clinically important.

Purpose of the Study:

  • To evaluate and compare the optic disk appearance in eyes with pseudoexfoliation syndrome (PES) versus other glaucoma types and normal eyes.
  • To determine if optic disk size is a predisposing factor for glaucoma in PES.
  • To identify any pathognomonic optic disk features associated with PES.

Main Methods:

  • Comparative analysis of clinical data and optic disk photographs.

Related Experiment Videos

  • Inclusion of patients with pseudoexfoliative glaucoma, nonglaucomatous pseudoexfoliation syndrome, primary open-angle glaucoma, and normal subjects.
  • Quantitative assessment of optic disk area, neuroretinal rim area, parapapillary atrophy zones, and retinal vessel diameters.

    • Main Results:

    • Optic disk area was significantly smaller in both glaucomatous and nonglaucomatous eyes with pseudoexfoliation compared to their respective controls.
    • No significant differences were observed in neuroretinal rim area, parapapillary atrophy, or retinal vessel diameters between pseudoexfoliative and non-pseudoexfoliative groups.
    • Intraocular pressure peaks were significantly higher in pseudoexfoliative glaucoma compared to primary open-angle glaucoma.

    Conclusions:

    • Optic disk appearance is largely similar between pseudoexfoliative glaucoma and primary open-angle glaucoma, apart from a smaller optic disk size in PES.
    • A small optic disk in pseudoexfoliation syndrome does not appear to predispose individuals to developing glaucoma.
    • The optic disk lacks specific, pathognomonic features for pseudoexfoliation syndrome, unlike the anterior segment.