Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Growth hormone-releasing peptides

E Ghigo1, E Arvat, G Muccioli

  • 1Department of Internal Medicine, University of Turin, Italy.

European Journal of Endocrinology
|May 1, 1997
PubMed
Summary

Growth hormone-releasing peptides (GHRPs) stimulate somatotrope secretion via specific receptors. These peptides, including non-peptidyl mimetics, show clinical utility for treating growth hormone deficiency.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Endocrinologists at work: management of hyponatremia in clinical practice.

Journal of endocrinological investigation·2023
Same author

Impact of allogeneic stem cell transplantation on thyroid function.

Journal of endocrinological investigation·2023
Same author

Benefits of dual-release hydrocortisone treatment on central adiposity and health-related quality of life in secondary adrenal insufficiency.

Journal of endocrinological investigation·2022
Same author

Impact of the SARS-CoV2 pandemic dissemination on the management of neuroendocrine neoplasia in Italy: a report from the Italian Association for Neuroendocrine Tumors (Itanet).

Journal of endocrinological investigation·2020
Same author

Reference ranges of late-night salivary cortisol and cortisone measured by LC-MS/MS and accuracy for the diagnosis of Cushing's syndrome.

Journal of endocrinological investigation·2020
Same author

Bone metastases from differentiated thyroid carcinoma: current knowledge and open issues.

Journal of endocrinological investigation·2020

Area of Science:

  • Endocrinology
  • Pharmacology

Background:

  • Growth hormone-releasing peptides (GHRPs) are synthetic peptides that stimulate somatotrope secretion.
  • They act via specific receptors, distinct from GHRH receptors, suggesting a natural ligand.
  • The exact mechanisms of GHRP action are still under investigation, possibly involving counteracting somatostatin or an unknown hypothalamic factor.

Purpose of the Study:

  • To review the properties and clinical applications of GHRPs and their mimetics.
  • To explore the mechanisms of action and factors influencing GHRP efficacy.
  • To assess the potential of GHRPs in treating growth hormone deficiency.

Main Methods:

  • Review of existing literature on GHRPs and their analogues.
  • Analysis of studies investigating GHRP mechanisms, administration routes, and effects in various physiological and pathological states.
  • Evaluation of clinical data on GHRP efficacy in different age groups and conditions.

Main Results:

  • GHRPs exhibit potent, dose-related GH-releasing activity via multiple administration routes, including oral.
  • Their efficacy is influenced by age, with peak activity during puberty and adulthood.
  • GHRPs maintain efficacy in hypersecretory states and show variable responses in hyposecretory states, with potential benefits in short children.

Conclusions:

  • GHRPs and their mimetics represent a promising class of compounds for stimulating GH secretion.
  • Their effectiveness, particularly after oral administration, highlights their clinical utility for managing GH deficiency.
  • Further research into their mechanisms and therapeutic applications is warranted.

Related Experiment Videos