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An index predicting coronary heart disease: LDL/HDL x 5
S Kimata1, S Hosoda, I Yokoyama
1Tokyo Women's Medical College, Aoyama Hospital, Japan.
Japanese Heart Journal
|January 1, 1997
Summary
A new index, LDL/HDL x 5, shows promise in predicting coronary heart disease events like angina and re-infarction. This indicator proved more sensitive than traditional cholesterol measures in study participants.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Atherosclerosis is driven by the balance of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol.
- LDL transports cholesterol to artery walls, while HDL removes it.
Purpose of the Study:
- To evaluate a novel index, LDL/HDL x 5, as a predictor of coronary heart disease.
- To assess its efficacy in primary and secondary prevention populations.
Main Methods:
- Calculated the LDL/HDL x 5 index for participants in a medical examination system.
- Compared the index's predictive power against total cholesterol, LDL, and HDL for effort angina.
- Evaluated the index in myocardial infarction patients to predict re-infarction.
Main Results:
- The LDL/HDL x 5 index was more sensitive in predicting effort angina than total cholesterol, LDL, or HDL.
- Patients with myocardial infarction (AMI) exhibited significantly lower HDL concentrations.
- The LDL/HDL x 5 index demonstrated higher sensitivity in predicting re-infarction compared to traditional markers.
Conclusions:
- The LDL/HDL x 5 index is a potentially valuable tool for predicting coronary heart disease.
- This index may improve risk stratification for both primary and secondary prevention of cardiovascular events.