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Related Experiment Videos

Protease inhibitors and urolithiasis

S E Sutherland1, M D Reigle, A D Seftel

  • 1Department of Urology, Case Western Reserve University, Cleveland, Ohio, USA.

The Journal of Urology
|July 1, 1997
PubMed
Summary

Protease inhibitor therapy for human immunodeficiency virus (HIV) can cause unusual urinary stones. Urologists must recognize these potential urological complications as HIV treatment evolves.

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Area of Science:

  • Urology
  • Nephrology
  • Infectious Diseases

Background:

  • Protease inhibitors are crucial in managing human immunodeficiency virus (HIV) infection.
  • Understanding the full spectrum of drug-related complications is essential for patient care.

Observation:

  • A case report of a human immunodeficiency virus positive patient on protease inhibitor therapy.
  • The patient presented with renal colic, indicating a urinary tract issue.

Findings:

  • The patient developed a urinary calculus (stone) during protease inhibitor treatment.
  • The stone's composition was atypical and did not match known urinary calculus types.
  • The stone passed spontaneously without intervention.

Implications:

  • The urological community needs awareness of potential urinary abnormalities linked to protease inhibitors.
  • Familiarity with these drugs and their urological complications is vital as their use expands in HIV management.

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