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The safety of transurethral prostatectomy: a cohort study of mortality in 9,416 men
E V Cattolica1, S Sidney, M C Sadler
1Department of Urology, Kaiser Permanente Medical Center, Oakland, California 94611-5693, USA.
Insights
Transurethral resection of the prostate (TURP) for benign prostatic hypertrophy (BPH) shows no increased mortality risk. This TURP safety data can inform patient treatment discussions.
Area of Science:
- Urology
- Surgical Outcomes
- Public Health
Background:
- Benign prostatic hypertrophy (BPH) affects a significant number of aging men.
- Transurethral resection of the prostate (TURP) is a common surgical intervention for BPH.
- Assessing the safety and mortality associated with TURP is crucial for patient care.
Purpose of the Study:
- To evaluate the mortality rate associated with transurethral resection of the prostate (TURP).
- To compare the mortality risk of TURP for benign prostatic hypertrophy (BPH) against a non-surgical cohort.
Main Methods:
- A retrospective cohort study comparing 4,708 patients undergoing TURP for BPH with 4,708 age-matched controls.
- Utilized proportional hazards models to determine the relative risk of mortality.
Main Results:
- The overall relative risk of mortality for TURP versus no surgery was 0.88 (95% CI: 0.82–0.95).
- Age-specific analyses also indicated a reduced or neutral risk of mortality, with relative risks ranging from 0.77 to 0.95.
Conclusions:
- Transurethral resection of the prostate (TURP) for benign prostatic hypertrophy (BPH) is not associated with excess mortality.
- The findings support the safety of TURP and provide valuable information for patient counseling regarding treatment options.
Purpose:
We assessed the mortality rate from transurethral resection of the prostate.
Materials And Methods:
From 1976 to 1984, 4,708 patients undergoing transurethral resection of the prostate for benign prostatic hypertrophy (BPH) were compared retrospectively to an age-matched group of 4,708 randomly selected Kaiser Permanente Medical Care Program members not undergoing surgery. The risk of mortality associated with transurethral resection of the prostate relative to no surgery was determined using proportional hazards models.
Results:
The relative risk for surgery versus no surgery for the total group was 0.88 (95% confidence interval 0.82 to 0.95). Similarly, the results for each 5-year age group demonstrated a relative risk of 0.77 to 0.95.
Conclusions:
This cohort study showed no excess mortality for patients undergoing transurethral resection of the prostate compared to age-matched comparison subjects randomly selected from health plan members who did not undergo surgery. Information from this study about the safety of transurethral resection of the prostate can be shared with patients when discussing treatment options.