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Updated: Aug 18, 2026
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
Published on: January 9, 2019
Evidence of optic pathway gliomas after previously negative neuroimaging
G G Massry1, C F Morgan, S M Chung
1Department of Ophthalmology, Anheuser-Busch Eye Institute, Saint Louis University Health Sciences Center, MO 63104, USA.
Purpose:
The authors emphasize the potential for the development of anterior visual pathway gliomas, evidenced by computed tomography (CT) or magnetic resonance imaging (MRI) scans, in neurofibromatosis type 1 (NF1) patients who previously had normal neuroimaging studies.
Methods:
The clinic charts and CT and MRI scans were retrospectively reviewed for all patients evaluated at the neurofibromatosis clinic of one referral center over a period of 7 years. Patients with neuroimaging studies demonstrating anterior visual pathway gliomas who previously had normal scans were identified, and their cases are described in detail. A similar, previously reported series, from the pediatric literature, was also reviewed.
Results:
Eight percent (28/360) of patients had CT or MRI scans revealing optic gliomas. Two of these patients had normal neuroimaging studies previously.
Conclusion:
A negative neuroimaging study in an NF1 patient does not exclude the future development of an optic glioma.
