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Minocycline-induced scleral pigmentation
1Department of Ophthalmology, Casey Eye Institute, Oregon Health Sciences University, Portland 97201-4197, USA.
Ophthalmology
|June 1, 1997
Summary
Oral minocycline, a common acne and rosacea treatment, can cause blue-gray scleral pigmentation. This side effect may resolve over time or be permanent.
Area of Science:
- Ophthalmology
- Dermatology
- Pharmacology
Background:
- Minocycline is frequently prescribed for acne and rosacea.
- Scleral pigmentation is a rare but reported side effect of minocycline therapy.
Observation:
- This study presents three new cases of probable minocycline-induced scleral pigmentation, adding to four previously reported cases.
- The characteristic pigmentation appears as a blue-gray band at the limbus, potentially exacerbated by photosensitivity.
Findings:
- Oral minocycline can induce scleral pigmentation, which may occur independently or with pigmentary changes in other tissues.
- The observed pigmentary changes can be permanent or may resolve over several years.
Implications:
- Ophthalmologists should be aware of this potential adverse drug reaction when treating patients on minocycline.
- Monitoring for scleral pigmentation is recommended in patients using oral minocycline for dermatologic conditions.