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Bilateral iridocyclitis with retinal capillaritis in juveniles
Ophthalmology
|June 1, 1997
Summary
This study describes a new form of uveitis called bilateral iridocyclitis with retinal capillaritis (BIRC) in 18 juvenile patients. Early diagnosis using fluorescein angiography and prompt corticosteroid treatment are key for managing this condition.
Area of Science:
- Ophthalmology
- Immunology
Background:
- Uveitis is a group of inflammatory eye diseases.
- Bilateral iridocyclitis with retinal capillaritis (BIRC) is a newly identified subtype of uveitis in juveniles.
Purpose of the Study:
- To present the clinical features of 18 juvenile patients diagnosed with bilateral iridocyclitis with retinal capillaritis (BIRC).
Main Methods:
- Retrospective review of medical records for 18 consecutive juvenile patients with BIRC from 1985-1995.
- Clinical examination, anterior segment imaging, and fluorescein angiography were utilized.
- Human leukocyte antigen (HLA) typing was performed.
Main Results:
- The study included 18 patients (12 female, 6 male) aged 9-17 years.
- All patients presented with bilateral iridocyclitis, mutton fat keratic precipitates, and retinal capillary leakage on fluorescein angiography.
- Good vision was maintained, and inflammation responded well to corticosteroids; HLA-DR6 and HLA-Cw7 were significantly associated with BIRC.
Conclusions:
- BIRC is characterized by bilateral retinal capillaritis and retinal cloudiness without distinct lesions.
- Fluorescein angiography is crucial for diagnosing BIRC.
- Corticosteroid therapy is effective in managing BIRC.