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Sarcoidosis and transplantation

M L Padilla1, G J Schilero, A S Teirstein

  • 1Mount Sinai Medical Center, Department of Medicine, New York, N.Y. 10029, USA.

Sarcoidosis, Vasculitis, and Diffuse Lung Diseases : Official Journal of WASOG
|March 1, 1997
PubMed
Summary

Organ transplantation is safe for patients with sarcoidosis, with similar survival and complication rates. Sarcoidosis recurrence is common after lung transplant but typically doesn't affect graft function or survival.

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Area of Science:

  • Transplant medicine
  • Immunology
  • Pulmonology

Background:

  • Sarcoidosis is a multisystem inflammatory disease.
  • Limited data exists on organ transplantation outcomes in sarcoidosis patients.
  • Previous reports suggest feasibility but lack systematic analysis.

Purpose of the Study:

  • To review and analyze existing literature on organ transplantation in sarcoidosis patients.
  • To assess survival, complications, and recurrence rates.
  • To understand the impact of sarcoidosis on transplant outcomes.

Main Methods:

  • Literature review of kidney, liver, heart, heart-lung, and lung transplant cases in sarcoidosis patients.
  • Analysis focused on patient survival, post-transplant complications, and sarcoidosis recurrence.
  • Inclusion of data from published reports and the UNOS International Registry.

Main Results:

  • Transplant survival and complication rates in sarcoidosis patients are comparable to those with other indications.
  • Pulmonary sarcoidosis recurrence post-lung transplantation is estimated at 47%.
  • Reported cases are a subset of the total patient population in registries.

Conclusions:

  • Organ transplantation is a safe therapeutic option for end-stage organ failure in sarcoidosis.
  • Sarcoidosis recurrence is frequent, often asymptomatic, and does not impair graft survival.
  • Recurrence symptoms are manageable with increased corticosteroid therapy; exacerbations linked to immunosuppression.

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