Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hyperthermia after cardiac surgery

K Abe1, Y Miyamoto, K Ohnishi

  • 1Department of Anaesthesiology, Osaka University Medical School, Japan. abe@anes.med.osaka-u.ac.jp

Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Different thresholds of HSP70 and HSC70 heat shock mRNA induction in post-ischemic gerbil brain.

Brain research·1992
Same author

[Mechanism of renin release and cellular action of angiotensin II].

Nihon Naibunpi Gakkai zasshi·1992
Same author

Ras (CXXX) and Rab (CC/CXC) prenylation signal sequences are unique and functionally distinct.

The Journal of biological chemistry·1992
Same author

Isolation of complementary DNAs for heat shock protein (HSP) 70 and heat shock cognate protein (HSC) 70 genes and the expressions in post-ischaemic gerbil brain.

Neurological research·1992
Same author

[DNA typing of HLA-class II genes in idiopathic nephropathy].

Nihon rinsho. Japanese journal of clinical medicine·1992
Same author

Effect of slow release nifedipine tablets in patients with essential hypertension.

Arzneimittel-Forschung·1992

Two patients developed severe hyperthermia after cardiac surgery, presenting with acidosis and elevated creatine phosphokinase. Dantrolene effectively reduced high rectal temperatures and improved acidosis in these cases.

Area of Science:

  • Cardiology
  • Anesthesiology
  • Critical Care Medicine

Background:

  • Cardiac surgery can involve complex procedures like cardiopulmonary bypass.
  • Protamine administration post-bypass can lead to adverse reactions, including hypotension and pulmonary hypertension.

Observation:

  • Two patients experienced severe hyperthermia (up to 41°C) and metabolic acidosis following protamine administration after cardiac surgery.
  • These patients also showed significantly elevated creatine phosphokinase and myoglobin levels, indicative of muscle damage.
  • Initial cooling measures were ineffective, but subsequent administration of dantrolene rapidly resolved the hyperthermia and acidosis.

Findings:

  • Dantrolene administration (400 mg and 200 mg) successfully reduced rectal temperatures to 37.5°C in both patients.

Related Experiment Videos

  • Arterial blood gas analysis normalized, with resolution of acidosis, hypoxemia, and hypercarbia after dantrolene treatment.
  • The first patient was diagnosed with an anaphylactoid reaction, confirmed by elevated plasma tryptase.

    • Implications:

    • Dantrolene appears to be a highly effective treatment for hyperthermia and associated metabolic derangements following cardiac surgery.
    • This suggests a potential role for dantrolene in managing specific post-cardiac surgery complications, possibly related to anaphylactoid reactions or other mechanisms causing hyperthermia.
    • Further investigation into the underlying mechanisms and optimal use of dantrolene in this context is warranted.