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Pediatric lung transplantation

P C Stillwell1, G B Mallory

  • 1Department of Pediatrics, Cleveland Clinic Foundation, Ohio, USA.

Clinics in Chest Medicine
|June 1, 1997
PubMed
Summary
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Pediatric lung transplantation is increasingly successful for conditions like cystic fibrosis. Survival rates for children undergoing lung transplants are comparable to adults, showing promising outcomes.

Area of Science:

  • Pediatric surgery
  • Thoracic surgery
  • Immunology

Background:

  • Pediatric lung transplantation is a growing field with improving outcomes.
  • Common indications include cystic fibrosis, pulmonary vascular disease, and fibrotic lung disease.
  • Transplant challenges in children share similarities with adults but have unique pediatric considerations.

Purpose of the Study:

  • To review the current status and outcomes of pediatric lung transplantation.
  • To highlight common indications, contraindications, and complications specific to pediatric recipients.
  • To discuss challenges faced by pediatric patients, particularly those with cystic fibrosis.

Main Methods:

  • Review of existing literature and clinical experience in pediatric lung transplantation.

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  • Analysis of common indications and contraindications.
  • Evaluation of post-transplant complications and survival data.

    • Main Results:

    • Lung transplantation in children is becoming more common and successful.
    • Cystic fibrosis, pulmonary vascular disease, and fibrotic lung disease are primary indications.
    • Post-transplant lymphoproliferative disorder and airway issues may be more frequent in children.

    Conclusions:

    • Pediatric lung transplantation offers survival rates comparable to adults (approx. 65% at 1 year, 69% at 2 years).
    • Cystic fibrosis patients encounter specific challenges, including infections and comorbidities.
    • Continued experience is enhancing the success of pediatric lung transplants.