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Ribosome-inactivating lectins with polynucleotide:adenosine glycosidase activity
M G Battelli1, L Barbieri, A Bolognesi
1Dipartimento di Patologia sperimentale dell'Università di Bologna, Italy.
FEBS Letters
|May 26, 1997
Abstract:
Lectins from Aegopodium podagraria (APA), Bryonia dioica (BDA), Galanthus nivalis (GNA), Iris hybrid (IRA) and Sambucus nigra (SNAI), and a new lectin-related protein from Sambucus nigra (SNLRP) were studied to ascertain whether they had the properties of ribosome-inactivating proteins (RIP). IRA and SNLRP inhibited protein synthesis by a cell-free system and, at much higher concentrations, by cells and had polynucleotide:adenosine glycosidase activity, thus behaving like non-toxic type 2 (two chain) RIP. APA and SNAI had much less activity, and BDA and GNA did not inhibit protein synthesis.