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Nasal immunotherapy in pollen-sensitive children

E Cserháti¹, G Mezei

¹1st Department of Paediatrics, Semmelweis Medical University, Budapest, Hungary.

|January 1, 1997

Summary

Local nasal immunotherapy offers a safe and effective alternative for children with allergic rhinitis. This study found nasal immunotherapy reduced symptoms and medication needs without severe side effects.

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Area of Science:

Allergy and Immunology
Otolaryngology

Background:

Subcutaneous immunotherapy carries significant risks, prompting research into safer alternatives.
Allergic rhinitis management often requires improved hyposensitization strategies.

Purpose of the Study:

To evaluate the efficacy and safety of local nasal immunotherapy (Allerkin) in children with seasonal allergic rhinitis.
To compare nasal immunotherapy with traditional treatments for grass and ragweed allergies.

Main Methods:

A study involving 36 children with grass or ragweed allergic rhinitis, divided into immunotherapy and control groups.
Methods included nasal provocation tests, skin prick tests, and symptom/medication diaries.
Treatment involved preseasonal nasal immunotherapy with increasing doses of Allerkin.

Main Results:

Nasal immunotherapy significantly increased tolerance thresholds and reduced symptoms and drug consumption in grass-allergic children.
Similar, though less pronounced, benefits were observed in ragweed-allergic children.
A significant reduction in the need for steroid treatment was noted after two years of immunotherapy, with minimal side effects.

Conclusions:

Local nasal immunotherapy is an effective and safe alternative to systemic immunotherapy for allergic rhinitis.
The Allerkin nasal immunotherapy demonstrated a favorable safety profile with mild, transient side effects.
Nasal immunotherapy presents a less troublesome option for managing seasonal allergic rhinitis in children.

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