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Microcephaly due to fetal brain disruption sequence. Case report

L Gabis1, Z Gelman-Kohan, M Mogilner

  • 1Department of Neonatology, Kaplan Hospital, Rehovot, Israel.

Journal of Perinatal Medicine
|January 1, 1997
PubMed
Summary

A pregnant individual experienced a car accident, leading to intrauterine microcephaly in the fetus. This condition, characterized by arrested brain development, is attributed to brain disruption sequence following the trauma.

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Area of Science:

  • Neurology
  • Obstetrics
  • Developmental Biology

Background:

  • Intrauterine microcephaly is a congenital condition where the fetal head circumference is significantly smaller than average.
  • Traumatic injuries during pregnancy can pose risks to fetal development.
  • Brain disruption sequence is a proposed mechanism for congenital anomalies resulting from disruptive events.

Observation:

  • A case of intrauterine microcephaly is presented.
  • The microcephaly was noted to have developed after a maternal car accident during the second trimester of pregnancy.
  • The onset of microcephaly was observed three weeks post-trauma.

Findings:

  • The described case suggests a potential link between maternal trauma and the development of intrauterine microcephaly.

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  • The findings support the hypothesis that the car accident induced a brain disruption sequence.
  • This sequence led to an arrest in fetal brain development.

    • Implications:

    • This case highlights the potential teratogenic effects of significant trauma during pregnancy.
    • Understanding brain disruption sequence is crucial for diagnosing and managing congenital anomalies post-trauma.
    • Further research is warranted to elucidate the precise mechanisms linking trauma and fetal brain development arrest.