Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Subthalamic stimulation elicits hemiballismus in normal monkey

C Beurrier1, E Bezard, B Bioulac

  • 1Laboratoire de Neurophysiologie, CNRS UMR 5543, Université de Bordeaux II, France.

Neuroreport
|May 6, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The current state of palliative care research in heart failure.

ESC heart failure·2026
Same author

SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition.

Journal of molecular and cellular cardiology plus·2026
Same author

Characterization of ferric hydroxysulfate on Mars and implications of the geochemical environment supporting its formation.

Nature communications·2025
Same author

Differential pathological dynamics triggered by distinct Parkinson patient-derived α-synuclein extracts in nonhuman primates.

Science advances·2025
Same author

Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space.

NPJ Parkinson's disease·2024
Same author

Comparative analysis of cell morphology in patient-paired primary human osteoblasts from the jaw and the fibula.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery·2024

High frequency stimulation (HFS) of the subthalamic nucleus (STN) alleviates parkinsonian symptoms in MPTP-treated monkeys. In normal monkeys, HFS induces dyskinesias by disinhibiting the thalamo-cortical pathway.

Area of Science:

  • Neuroscience
  • Movement Disorders
  • Neurosurgery

Background:

  • High frequency stimulation (HFS) of the subthalamic nucleus (STN) is effective in treating parkinsonian symptoms in humans and MPTP-treated monkeys.
  • The effects of STN HFS on normal primate motor function remain largely uncharacterized.

Purpose of the Study:

  • To investigate the effects of STN HFS on motor behavior in normal awake primates.
  • To elucidate the mechanisms underlying STN HFS-induced motor alterations in both normal and MPTP-treated primate models.

Main Methods:

  • High frequency stimulation (HFS) was applied to the subthalamic nucleus (STN) in normal and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys.
  • Motor behavior, including dyskinesias and parkinsonian symptoms (akinesia, rigidity), was assessed.

Related Experiment Videos

  • Neurophysiological mechanisms involving the thalamo-cortical pathway and basal ganglia circuitry were inferred.

    • Main Results:

    • In normal monkeys, HFS of the STN induced contralateral dyskinesias, resembling hemiballismus, suggesting STN incapacitation and thalamo-cortical pathway disinhibition.
    • Low frequency stimulation of the STN had no discernible effect on motor behavior in normal monkeys.
    • In MPTP-treated monkeys, HFS of the STN reduced overactivity, alleviating akinesia and rigidity by modulating basal ganglia output to the globus pallidus.

    Conclusions:

    • STN HFS has differential effects in normal versus parkinsonian states, inducing involuntary movements in healthy primates but therapeutic benefits in MPTP models.
    • The findings highlight the critical role of the STN in motor control and suggest distinct circuit dysfunctions in Parkinson's disease.
    • Understanding these differential effects is crucial for optimizing STN deep brain stimulation therapies for movement disorders.