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Related Experiment Videos

[Pleomorphic xanthoastrocytoma]

I Vajtai1, Z Varga

  • 1Neuropathologiai Intézet, Universitätsspital Zürich.

Orvosi Hetilap
|April 20, 1997
PubMed
Summary
This summary is machine-generated.

Pleomorphic xanthoastrocytoma (PXA) is a rare brain tumor. Immunohistochemical analysis of 8 cases revealed glial markers and focal neuronal markers, with low proliferation rates, suggesting a generally favorable prognosis.

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Area of Science:

  • Neuro-oncology
  • Surgical pathology
  • Molecular diagnostics

Context:

  • Pleomorphic xanthoastrocytoma (PXA) is a rare, slow-growing brain tumor typically affecting young adults.
  • PXA often presents superficially with meningeal involvement and histological atypia.
  • Distinguishing PXA subtypes and assessing anaplastic features are critical for prognosis.

Purpose:

  • To perform a retrospective immunohistochemical analysis of 8 surgically treated PXA cases.
  • To determine the expression of glial and neuronal markers in PXA.
  • To assess the proliferating cell fraction using MIB-1 and evaluate prognostic factors.

Summary:

  • Eight PXA cases (1 female, 7 male; mean age 26.7 years) were analyzed. Tumors were predominantly temporal lobe, with epilepsy as the main symptom.

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  • WHO grade II (n=5) showed 2.05% MIB-1 labeling, while WHO grade III (n=3) showed 4.66% labeling. All tumors expressed glial fibrillary acidic protein (GFAP); focal synaptophysin was observed in 7 cases.
  • Recurrence was noted in only one anaplastic case after a mean follow-up of 6.7 years. The study discusses diagnostic challenges and potential dysontogenic origins.

    • Impact:

    • Provides insights into the immunohistochemical profile of PXA, aiding in diagnosis and classification.
    • Highlights the low proliferation rates and generally favorable prognosis, even in anaplastic cases.
    • Contributes to the understanding of PXA's nosologic relationship with other neuroepithelial tumors.