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Absence of neuroanatomical and behavioral deficits in L7/pcp-2-null mice
G Vassileva1, R J Smeyne, J I Morgan
1Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Brain Research. Molecular Brain Research
|June 1, 1997
Abstract:
L7/pcp-2 is expressed exclusively in cerebellar Purkinje and retinal bipolar neurons. While the function of L7/pcp-2 is unknown, its mRNA is trafficked into dendrites, suggesting a role in dendritic physiology. To elucidate its function, L7/pcp-2-null mice were generated. These mice are neurologically normal with no signs of cerebellar or retinal dysfunction. The mice are indistinguishable from wild-type littermates with regards to gross neuroanatomy and fine structure of Purkinje cell dendrites.