Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

T-lymphocyte-fibroblast interactions

J G Crowston1, M Salmon, P T Khaw

  • 1Department of Immunology, Royal Free Hospital, London, U.K.

Biochemical Society Transactions
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Age-Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy.

Aging cell·2025
Same author

Biosynthesis and bioactivity of anti-inflammatory triterpenoids in Calendula officinalis.

Nature communications·2025
Same author

Adaptation of sea turtles to climate warming: Will phenological responses be sufficient to counteract changes in reproductive output?

Global change biology·2023
Same author

Self-rated health in individuals with and without disease is associated with multiple biomarkers representing multiple biological domains.

Scientific reports·2021
Same author

Development of Real-Time RT-PCR Assay for Detection of Prunus necrotic ringspot virus in Fruit Trees.

Plant disease·2019
Same author

Development of Real-Time PCR for the Rapid Detection of Episomal Banana streak virus (BSV).

Plant disease·2019
Same journal

TDP-43 proteinopathy as a biomarker and therapeutic target in amyotrophic lateral sclerosis.

Biochemical Society transactions·2026
Same journal

Advancing the monitoring of organelle contact sites in vitro and in vivo.

Biochemical Society transactions·2026
Same journal

Mechanisms influencing transient cytoplasmic protein targeting to intracellular lipid droplets.

Biochemical Society transactions·2026
Same journal

Replication associated nuclear DNA mismatch repair across kingdoms.

Biochemical Society transactions·2026
Same journal

Phosphatases of regenerating liver downregulate PTEN to promote tumorigenesis.

Biochemical Society transactions·2026
Same journal

Implications of Rho GTPase signaling in cancer immunotherapy.

Biochemical Society transactions·2026
See all related articles

Fibroblasts influence T-cell survival, impacting immune responses and chronic inflammation. Manipulating this interaction offers therapeutic potential for conditions like AIDS and scarring.

Area of Science:

  • Immunology
  • Cell Biology
  • Dermatology

Background:

  • Activated T-cells undergo apoptosis post-immune response.
  • Cytokine deprivation induces T-cell apoptosis, inhibitable by exogenous cytokines or fibroblast survival factors.
  • Fibroblast-mediated T-cell survival can lead to chronic inflammation or persistent immune memory.

Purpose of the Study:

  • To investigate the role of fibroblast-mediated T-cell survival in immune responses and disease.
  • To explore the therapeutic potential of manipulating T-cell-fibroblast interactions.

Main Methods:

  • Review of evidence from wound healing studies.
  • Analysis of T-cell and fibroblast interactions.

Main Results:

Related Experiment Videos

  • Fibroblast survival factors inhibit T-cell apoptosis, potentially prolonging T-cell persistence.
  • Bidirectional interaction exists between T-cells and fibroblasts.
  • Persistent T-cells in wounds can exacerbate scarring.

Conclusions:

  • Modulating T-cell-fibroblast interactions presents novel therapeutic strategies.
  • Targeting fibroblast survival factors could treat chronic inflammation, lymphopenic states (e.g., AIDS), and excessive scarring.