Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ultrastructural changes in gentamicin nephrotoxicity

S R Acchiardo, W M Murphy

    Urology
    |October 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    This study details the kidney ultrastructural changes in a patient experiencing acute renal failure due to gentamicin. Electron microscopy revealed specific cellular damage, enhancing our understanding of this common drug toxicity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dialysis catheter-induced superior vena cava syndrome and downhill esophageal varices.

    Clinical nephrology·2007
    Same author

    A finite element stress analysis of the transmandibular implant system.

    The International journal of prosthodontics·2002
    Same author

    An enzyme hydrolyzing methylated inhibitors of nitric oxide synthase is present in circulating human red blood cells.

    Free radical research·2002
    Same author

    Human carcinogenesis, the new genetics, and the practicing pathologist.

    Polish journal of pathology : official journal of the Polish Society of Pathologists·2002
    Same author

    Implications for the role of endogenous nitric oxide inhibitors in hemodialysis hypotension.

    Free radical research·2001
    Same author

    A long-term, multicenter study of the efficacy and safety of paricalcitol in end-stage renal disease.

    Clinical nephrology·2001
    Same journal

    Preventing Postpartum Pelvic Floor Dysfunction: Clinical Evidence and Policy Gaps in U.S. Coverage of Pelvic Floor Muscle Therapy.

    Urology·2026
    Same journal

    Editorial Comment on "Through the Eyes of the Applicant: A Qualitative Study of the Urology Residency Match".

    Urology·2026
    Same journal

    Editorial Comment on "A Histopathologic Assessment of Prostate Ductal Anatomy in Relation to Micro-Ultrasound".

    Urology·2026
    Same journal

    Same-Day Discharge Following Multiport Robot-Assisted Simple Prostatectomy: A Prospective Feasibility Study of Outcomes, Costs, and Post-Discharge Healthcare Utilization.

    Urology·2026
    Same journal

    Extended versus Standard Lymph Node Dissection at the Time of Radical Cystectomy for Bladder Cancer.

    Urology·2026
    Same journal

    Intractable Epistaxis and Severe Hypertension in a Young Woman.

    Urology·2026
    See all related articles

    Area of Science:

    • Nephrology
    • Pathology
    • Pharmacology

    Background:

    • Gentamicin is a common antibiotic associated with nephrotoxicity.
    • Previous studies on gentamicin-induced kidney damage primarily focused on animal models.
    • Ultrastructural changes in human kidneys from gentamicin toxicity remain poorly documented.

    Observation:

    • This report presents a case study of a patient with gentamicin-induced acute renal failure.
    • Clinical and pathological features were meticulously recorded.
    • Special emphasis was placed on electron microscopic examination of kidney tissue.

    Findings:

    • Electron microscopy revealed specific ultrastructural alterations in the renal tubules.
    • These findings provide detailed insights into the cellular mechanisms of gentamicin nephrotoxicity in humans.

    Related Experiment Videos

  • The observed changes correlate with the clinical presentation of acute kidney injury.

    • Implications:

    • This case report enhances the understanding of gentamicin's direct effects on human kidney cells.
    • The findings can inform clinical practice regarding gentamicin use and monitoring.
    • Further research into preventing or mitigating gentamicin-induced kidney damage is warranted.