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An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
CT of experimental hepatoma using the hepatocyte-specific lipid emulsion FP 736-03
A Bergman1, A Sundin, A Magnusson
1Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
Purpose:
The aim of the study was to investigate whether moderately to well differentiated hepatocellular carcinomas (HCC) possess the same ability to take up a new lipid emulsion contrast medium, FP 736-03, as do hepatocytes.
Material And Methods:
A rat model of an experimental HCC was used. CT was performed before and after an i.v. bolus injection of 1.0 ml FP 736-03/kg b.w. Attenuation values of normal liver parenchyma and tumour tissue were measured over time.
Results:
The contrast medium was taken up by the normal liver parenchyma but not by the tumour tissue for which the attenuation remained virtually constant over the observation period.
Conclusion:
The study demonstrated that FP 736-03 was not taken up by the HCC, thus producing a high lesion-to-liver contrast.
