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Left ventricular diastolic function in young men with high normal blood pressure
E Escudero1, S De Lena, S Graff-Iversen
1Centra de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina.
The Canadian Journal of Cardiology
|October 1, 1996
Summary
Young men with high normal blood pressure show altered left ventricular filling patterns, indicating potential early relaxation impairment. This shift to late diastolic filling may precede hypertension.
Area of Science:
- Cardiology
- Physiology
- Hypertension Research
Background:
- Abnormal left ventricular (LV) diastolic filling is observed in hypertensive individuals.
- Understanding early changes in LV diastolic function is crucial for hypertension prediction.
Purpose of the Study:
- To compare left ventricular (LV) diastolic filling between young men with high normal blood pressure (HNBP) and optimal blood pressure (OBP).
Main Methods:
- Selected 2 groups of young men (age 21): Group A (OBP) and Group B (HNBP).
- Assessed anthropometrics, LV structure, and systolic/diastolic function using echocardiography.
- Compared habits, body mass index, and LV mass index (LVMI).
Main Results:
- Higher LVMI in HNBP group, though not indicative of hypertrophy.
- Altered LV diastolic filling pattern in HNBP group, with reduced peak late diastolic flow velocity (A) and E:A ratio.
- HNBP group showed a shift towards more prominent late diastolic filling.
Conclusions:
- Young men with HNBP exhibit an early shift in LV filling, favoring atrial contraction.
- This pattern may indicate impaired LV relaxation, an early sign preceding hypertension.
- LV filling changes were independent of inheritance, age, sex, heart rate, habits, or BMI.