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Lymphoproliferative disorders and motor neuron disease: an update
P H Gordon1, L P Rowland, D S Younger
1Department of Neurology, Columbia-Presbyterian Medical Center, NY 10032-2699, USA.
Neurology
|June 1, 1997
Summary
This study examined 26 patients with motor neuron disease and lymphoproliferative disease (LPD), finding neurologic issues were the primary cause of disability or death. Treatment for LPD showed limited success in improving or halting neurologic decline.
Area of Science:
- Neurology
- Oncology
- Hematology
Background:
- Co-occurrence of motor neuron disease (MND) and lymphoproliferative disease (LPD) is rare.
- Understanding the clinical presentation and outcomes of this dual diagnosis is crucial.
Purpose of the Study:
- To investigate the clinical characteristics, neurologic manifestations, and outcomes of patients with concurrent MND and LPD.
- To assess the impact of LPD treatment on neurologic status in affected individuals.
Main Methods:
- Retrospective analysis of 26 patients diagnosed with both MND and LPD.
- Review of patient records for neurologic signs, LPD types, bone marrow involvement, and paraproteinemia.
- Evaluation of treatment responses and patient outcomes.
Main Results:
- Twenty-three patients exhibited upper motor neuron signs; no electrophysiologic evidence of motor neuropathy was found.
- Common LPDs included Waldenström's macroglobulinemia, multiple myeloma, and various leukemias/lymphomas.
- Neurologic complications were the primary cause of morbidity and mortality, with limited improvement following LPD treatment.
- POEMS syndrome was noted as an unusual concomitant finding.
Conclusions:
- Neurologic dysfunction is the predominant issue in patients with MND and LPD.
- Lymphoproliferative disease treatment offers minimal benefit for the neurologic decline associated with this comorbidity.
- Further research is needed to understand the pathogenic mechanisms and develop effective treatments.