Protein tyrosine phosphatase roles in the regulation of lymphocyte signaling

Tyrosine phosphorylation-based signaling cascades represent an integral component of the signaling circuitry connecting extracellular stimuli to cell response. As the molecular elements which drive such cascades have become increasingly well-characterized, appreciation has grown for the critical roles played by protein tyrosine phosphatases (PTPs) in intracellular signal relay and for the capacity of PTPs to act not only as a counterbalance for protein kinase activities, but also as pivotal enzymes in directing and modulating signal relay and the translation of given stimuli to cell behaviour. PTP function has been particularly well studied in relation to lymphocyte antigen receptor signaling and the results of these studies have provided many novel and significant insights into the biochemical mechanisms whereby PTPs participate in the integration and interpretation of the complex transmembrane stimulatory signals driving cell function and development.