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Association of alcohol consumption with HDL subpopulations defined by apolipoprotein A-I and apolipoprotein A-II
A Branchi1, A Rovellini, C Tomella
1Institute of Internal Medicine and Medical Physiopathology IRCCS Maggiore Hospital, University of Milan, Italy.
Objective:
To investigate the relationship between alcohol intake and serum level of high-density lipoprotein (HDL) subfractions defined on the basis of their apolipoprotein A-I and A-II content (LpA-I and LpA-I: A-II).
Design:
Observational study.
Setting:
Institute of Internal Medicine and Medical Physiopathology, IRCCS Maggiore Hospital, University of Milan.
Subjects:
One hundred healthy males with a mean age of 42 +/- 11.1 y, selected among blood donors.
Results:
Both LpA-I and LpA-I:A-II were significantly higher in men drinking more than 30 g a day of alcohol than in non-drinkers (LpA-I: difference between means 6.5 mg/dL, 95% C.I. 1.14-11.9; LpA-I:A-II difference between means 11.5 mg/dL, 95% C.I. 0.52-22.5). The association of alcohol consumption with LpA-I and LpA-I:A-II levels was independent from age, body mass index, physical activity, serum triglycerides and diet composition.
Conclusions:
Alcohol consumption is associated with an increase of serum levels of both LpA-I and LpA-I:A-II particles and this may, at least in part, explain the reduced cardiovascular morbidity observed in subjects drinking moderate amounts of alcoholic beverages.
Sponsorship:
Supported by grants from Ricerca Corrente Ospedale Maggiore di Milano IRCCS, Milan Italy.