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Spontaneous listeric encephalitis in sheep. Electron microscopic studies

K M Charlton

    Veterinary Pathology
    |September 1, 1977
    PubMed
    Summary

    Sheep with listeric encephalitis showed brainstem inflammation and tissue damage. Macrophages and neutrophils engulfed bacterial debris, indicating a severe central nervous system infection.

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    Area of Science:

    • Veterinary Neurology
    • Pathology
    • Infectious Diseases

    Background:

    • Listeric encephalitis is a serious neurological disease in sheep.
    • Spontaneous cases provide insights into disease progression and host response.

    Purpose of the Study:

    • To characterize the neuropathological findings in sheep with spontaneous listeric encephalitis.
    • To identify the types of inflammatory cells and their roles in tissue damage and bacterial clearance.

    Main Methods:

    • Histopathological examination of brainstem tissues from four affected sheep.
    • Light microscopy to identify inflammatory cells, neuronal degeneration, and bacterial presence.

    Main Results:

    • Lesions included inflammatory cell foci, nerve fiber degeneration, and malacia in the pons and medulla oblongata.
    • Macrophages and neutrophils phagocytosed myelin and axon debris, with neutrophils containing bacteria.
    • Bacteria were occasionally found in phagocytes, neurons, and axons.

    Conclusions:

    • Sheep listeric encephalitis involves significant brainstem inflammation and neuronal damage.
    • Phagocytic cells play a role in clearing debris, but bacterial clearance may be limited.
    • Histopathology is crucial for diagnosing and understanding the pathogenesis of this condition.

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