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Central neurofibromas in two dogs

M Vandevelde, K G Braund, E J Hoff

    Veterinary Pathology
    |September 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Two dogs developed central nervous system fibrous tumors. Histological analysis revealed these were central neurofibromas, originating from nerve sheaths.

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    Area of Science:

    • Veterinary Neurology
    • Comparative Pathology
    • Oncology

    Background:

    • Fibrous tumors in the central nervous system (CNS) of dogs are rare.
    • Understanding the origin and classification of these CNS tumors is crucial for diagnosis and treatment.

    Observation:

    • Two canine patients presented with distinct CNS fibrous tumors.
    • One tumor affected the spinal cord and ventral nerve root.
    • The second tumor was located in the midbrain and posterior brain stem.

    Findings:

    • Histopathological examination revealed spindle-shaped cells in rhythmic patterns.
    • Perivascular tumor cell infiltration into adjacent parenchyma was observed.
    • Tumor cells exhibited fibroblast-like morphology and appeared to produce collagen.

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  • Based on location near nerve roots and characteristic histology, tumors were classified as central neurofibromas.

    • Implications:

    • This case series contributes to the understanding of canine central nervous system neoplasms.
    • The findings highlight the importance of histological evaluation for accurate tumor classification.
    • Accurate classification of central neurofibromas can inform prognosis and potential therapeutic strategies in veterinary oncology.