Related Experiment Videos
Propylthiouracil-induced alveolar haemorrhage associated with antineutrophil cytoplasmic antibody
M Ohtsuka1, Y Yamashita, M Doi
1Dept of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki, Japan.
The European Respiratory Journal
|June 1, 1997
Abstract:
Propylthiouracil (PTU) is known to cause vasculitis as a rare complication. We report the case of a patient who developed alveolar haemorrhage and haematuria whilst treated with PTU. The serum was positive for antineutrophil cytoplasmic antibody (ANCA) with myeloperoxidase (MPO) specificity (MPO-ANCA). All symptoms resolved completely after discontinuation of PTU. Alveolar haemorrhage or pulmonary-renal syndrome associated with antineutrophil cytoplasmic antibody with myeloperoxidase specificity may be a new complication of propylthiouracil therapy.