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Is post-operative radiation for renal cell carcinoma justified?
I Aref1, R G Bociek, D Salhani
1Ottawa Regional Cancer Centre, Ontario Cancer Treatment and Research Foundation, Canada.
Purpose:
To identify the pattern of failure in patients with resected renal cell carcinoma (RCC).
Materials And Methods:
The records of 116 patients with unilateral, non-hematogenous metastatic RCC who were treated with definitive surgery and referred to the Ottawa Regional Cancer Centre between 1977 and 1988 were reviewed. Distribution by stage included T1 (3 patients), T2 (42 patients) and T3 (71 patients). The median follow-up was 44 months, with a range of 4-267 months.
Results:
Local regional failure (LRF) developed in 8 patients. Nine patients developed local or regional recurrence, plus distant failure. Fifty-eight patients had distant metastases (DM) only. The 7-year actuarial rate for LRF and DM were 12%, and 67%, respectively. The overall 7-year actuarial survival rate was 35%, and cause-specific survival was 42%.
Conclusions:
LRF alone is rare following nephrectomy. DM is the main pattern of failure. This data does not support the role of adjuvant radiation therapy in this disease.