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Decreased serotonin function in bulimia nervosa

D C Jimerson1, B E Wolfe, E D Metzger

  • 1Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, Mass, USA.

Archives of General Psychiatry
|June 1, 1997
PubMed
Summary

Patients with bulimia nervosa show reduced serotonin function, indicated by lower prolactin response to fenfluramine. This impaired serotonin responsiveness may contribute to binge eating behaviors in bulimia nervosa.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Endocrinology

Background:

  • Antidepressant medications targeting serotonin reduce binge eating in bulimia nervosa.
  • This suggests a link between serotonergic neurotransmitter function and bulimia nervosa symptoms.

Purpose of the Study:

  • To evaluate the hypothesis that abnormal serotonergic function contributes to bulimia nervosa.
  • To compare serotonin function in patients with bulimia nervosa and healthy controls using pharmacological challenge testing.

Main Methods:

  • Compared neuroendocrine response patterns in 15 women with bulimia nervosa and 14 healthy controls.
  • Assessed serotonergic response by measuring serum prolactin increase after d,l-fenfluramine administration.
  • Included behavioral assessments of eating disorder symptoms, depression, and anxiety.

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Main Results:

  • Patients with bulimia nervosa had a significantly lower fenfluramine-stimulated prolactin increase compared to controls.
  • A significant inverse correlation was found between binge eating frequency and serotonin-stimulated prolactin secretion in patients.

Conclusions:

  • Provides evidence for impaired central nervous system serotonergic responsiveness in bulimia nervosa.
  • Impaired serotonergic responsiveness may contribute to abnormal eating patterns in bulimia nervosa.