[Combined chemotherapy of lymphogranulomatosis]

Fourty two patients with lymphogranulomatosis (LG), mainly in stage IIIB and IVB, received polychemotherapy- a combination of N-nitrosomethyl urea, vinblastine, natulan and prednisolone (scheme L-I). The treatment comprised repeated courses. The first course lasted for 3 weeks, the remaining-for 2 weeks. An objective effect estimated by figure "3" was noted in 33 (78.6%) patients, "2"--in 6 (14.3%), "1"--in 2 (4.7%) and "o"-in 1 patients (2.4%). In 25 out of 33 patients with the objective effect "3" the complete clinical remission was gained, being maintained in 21. An average duration of the remission was 14 months. In overwhelming majority of case the maximum effect of the treatment was observed after the first (1-3) course of polychemotherapy. No grave complications relative to the treatment were noted.