[Tissue distribution of methylsulfonyl metabolites derived from Kanechlor 400 in mice]

Kanechlor 400, which caused the "Yusho disease", was i.p. administered to mice and methylsulfonyl (MeSO2) metabolites were investigated with respect to the concentration in liver and lung during 28 days after the administration. Major components were 3- and 4-MeSO2 derivatives from seven PCBs (IUPAC no. #31, #49, #64, #70, #101, #110, #132). In the liver, similar concentration ratio of 3- and 4-MeSO2 derivatives was observed, whereas seven 4-MeSO2 derivatives were selectively retained in the lung. Methylsulfone metabolites of triCB (#31) were rapidly formed and eliminated. The highest concentration of the metabolites in the lung was 4-MeSO2-2, 2', 4', 5-tetraCB. Concentration ratio of MeSO2-CBs to residual PCBs was 1:2.1 in the liver whereas 4.6:1 in the lung 28 days after the administration.