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Suppression of ischemic edema in mice by manganese-hyaluronate conjugate
1Toin Human Science and Technology Center, Department of Materials Science and Technology, Toin University of Yokohama, Japan.
Japanese Journal of Pharmacology
|May 1, 1997
Abstract:
Manganese-hyaluronate conjugate (Mn-HA) was synthesized from a diethylenetriaminepenta-acetic acid derivative of hyaluronic acid and manganese ion. The conjugate markedly scavenged super-oxide anion in vitro and exhibited much higher anti-inflammatory activity than superoxide dismutase in suppressing paw edema in mice when intravenously injected 30 min before the initiation of ischemia.