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Intradermal urate tophi

A G Fam1, D Assaad

  • 1Department of Medicine, Sunnybrook Health Science Centre, University of Toronto, Canada.

The Journal of Rheumatology
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Intradermal urate tophi, rare skin manifestations of gout, present as pustule-like lesions. Risk factors include renal failure, hypertension, and diuretic use, often leading to inflammation and ulceration.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Nephrology

Background:

  • Intradermal urate tophi are rare cutaneous manifestations of chronic tophaceous gout.
  • Understanding their clinical features and associated risk factors is crucial for diagnosis and management.

Purpose of the Study:

  • To analyze the clinical characteristics of intradermal urate tophi.
  • To identify risk factors contributing to their development in patients with gout.

Main Methods:

  • A case series involving six patients diagnosed with intradermal tophi between 1987 and 1996.
  • Clinical data, including patient history, physical examination, and laboratory findings, were reviewed.

Main Results:

  • Intradermal tophi presented as superficial, pustule-like lesions, often with inflammatory episodes, pain, swelling, and erythema.

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  • Five patients experienced ulceration with drainage of chalky material containing monosodium urate crystals.
  • Common risk factors identified were renal failure (all patients), hypertension (4 patients), and chronic diuretic therapy (4 patients).

    • Conclusions:

    • Intradermal tophi are rare but distinct skin manifestations of chronic gout, characterized by inflammation, ulceration, and potential pigmentary changes.
    • Renal insufficiency, hypertension, and diuretic use are significant risk factors associated with hyperuricemia and the development of gout and tophi.