Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effects on complement activation of a new continuous autotransfusion system

A Bengtsson1, A Avall, M Tylman

  • 1Department of Anaesthesiology & Intensive Care, Sahlgrenska University Hospital, Gothenburg, Sweden.

Transfusion Medicine (Oxford, England)
|June 1, 1997
PubMed
Summary

This study found that the Fresenius CATS autotransfusion system effectively removes inflammatory complement mediators. However, the processed blood contains high levels of free hemoglobin, a potential concern for patients receiving autologous blood transfusions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of disorder-free localization using a (2+1)D lattice gauge theory on a quantum processor.

Science (New York, N.Y.)·2026
Same author

Clinical and histopathological features of a population-based cohort of 95 consecutive patients with immunoglobulin G4-related disease in Stockholm, Sweden, during a five-year period.

Scandinavian journal of rheumatology·2026
Same author

Visualizing dynamics of charges and strings in (2 + 1)D lattice gauge theories.

Nature·2025
Same author

Scaling and logic in the colour code on a superconducting quantum processor.

Nature·2025
Same author

Thermalization and criticality on an analogue-digital quantum simulator.

Nature·2025
Same author

Altered medial temporal lobe subregion volumes in systemic lupus erythematosus patients with neuropsychiatric symptoms.

BMC rheumatology·2025

Area of Science:

  • Transfusion Medicine
  • Immunology
  • Biomedical Engineering

Background:

  • Allogeneic blood transfusions carry risks like infection and allergic reactions.
  • Autotransfusion techniques aim to mitigate these risks by reinfusing a patient's own blood.
  • The Fresenius CATS is a continuous autotransfusion system requiring evaluation.

Purpose of the Study:

  • To assess the impact of the Fresenius CATS on the complement system.
  • To evaluate the effects on erythrocytes and leucocytes during autotransfusion.
  • To analyze the composition of the retransfused blood.

Main Methods:

  • Eighteen hip replacement surgery patients were studied.
  • Complement variables (C4d, factor Bb, C3a, SC5b-9) and blood components were measured pre- and post-transfusion.

Related Experiment Videos

  • Analysis included blood in the reservoir, waste bag, and retransfused product.

    • Main Results:

    • Elevated C3a and SC5b-9 concentrations were observed in collected reservoir blood.
    • Washing and centrifugation significantly reduced these complement activation markers.
    • The processed blood exhibited high concentrations of free hemoglobin (median 260g/L).

    Conclusions:

    • The continuous autotransfusion technique effectively removes inflammatory mediators from the complement cascade.
    • The processed blood product contains substantial levels of free hemoglobin.
    • Further research is needed to address the implications of free hemoglobin in autotransfused blood.