Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function

F J Martinez1, M M de Oca, R I Whyte

  • 1Division of Pulmonary and Critical Care Medicine, University of Michigan Medical Center, Ann Arbor, USA.

American Journal of Respiratory and Critical Care Medicine
|June 1, 1997
PubMed
Summary

Lung-volume reduction surgery (LVRS) improves lung elastic recoil and respiratory muscle function in severe COPD patients. This leads to reduced dynamic hyperinflation, decreased dyspnea, and enhanced exercise capacity, benefiting selected individuals with emphysema.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Latent Space Projections and Atlases, a Cautionary Tale in Deep Neuroimaging using Autoencoders.

International journal of neural systems·2026
Same author

The GOLD Summit on chronic obstructive pulmonary disease in low- and middle-income countries.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2019
Same author

Owl Pellets, a Useful Method to Study Epigean Tenebrionid Beetles in Arid Lands.

Neotropical entomology·2019
Same author

Analysis of clinical diagnosis for all patients receiving antenatal betamethasone in a community hospital.

Journal of neonatal-perinatal medicine·2018
Same author

Determining major factors controlling phosphorus removal by promising adsorbents used for lake restoration: A linear mixed model approach.

Water research·2018
Same author

Patient Related Outcomes-BODE (PRO-BODE): A composite index incorporating health utilization resources predicts mortality and economic cost of COPD in real life.

Respiratory medicine·2017

Area of Science:

  • Pulmonary Medicine
  • Thoracic Surgery
  • Respiratory Physiology

Background:

  • Lung-volume reduction surgery (LVRS) is known to improve static lung elastic recoil in severe COPD patients.
  • However, the mechanisms behind clinical improvement, especially in patients without FEV1 changes post-LVRS, require further elucidation.
  • Understanding these mechanisms is crucial for optimizing patient selection and surgical outcomes.

Purpose of the Study:

  • To prospectively evaluate the effects of bilateral LVRS on pulmonary function, lung elastic recoil, and respiratory muscle (RM) function in severe COPD patients.
  • To assess changes in dynamic hyperinflation, exercise capacity, and dyspnea following LVRS.
  • To explore the correlation between changes in dynamic hyperinflation, respiratory muscle function, and perceived dyspnea.

Main Methods:

Related Experiment Videos

  • Seventeen patients with severe COPD underwent bilateral LVRS via median sternotomy.
  • Pre- and post-operative assessments included pulmonary function tests, lung elastic recoil, walking distance, exercise capacity, static and dynamic RM function, and dyspnea.
  • Dynamic hyperinflation (end-expiratory and end-inspiratory lung volumes) was quantified in 12 patients.

Main Results:

  • LVRS significantly improved FEV1, reduced total lung capacity and residual volume, and decreased both isowork dyspnea (VAS and Borg scale) and walking distance.
  • Dynamic hyperinflation (EELV and EILV) decreased at rest and during exercise post-LVRS.
  • Maximal transdiaphragmatic pressure increased, and dynamic RM function improved significantly at isowork, correlating strongly with reduced dynamic hyperinflation and dyspnea.

Conclusions:

  • Successful LVRS improves lung elastic recoil, reduces dynamic hyperinflation, and enhances respiratory muscle function in selected severe COPD patients.
  • These physiological improvements contribute to decreased dyspnea and better exercise capacity.
  • The findings enhance the understanding of LVRS mechanisms, supporting its role in managing severe emphysema.